Buy ketamine Nasal Spray

Description

Buy Ketamine Nasal Spray

Ketamine nasal spray acts by blocking receptors in the brain called NMDA receptors. The blockade of these receptors leads to increased mTOR pathway signaling, increased AMPA receptor activation, and increased development and efficacy of synapses in the brain, leading to an anti-depressant effect.

Ketamine has been used for several years in smaller doses in IV form to treat patients with treatment-resistant depression. However, as a generic drug, it has not undergone the FDA review process for that purpose. Now available is Ketamine nasal spray, a controlled substance sometimes used recreationally and known as Special K.

Results Conducted From Studies
According to Dr. Anand, individuals who use the new ketamine nasal spray may experience sensations of dissociation and hallucination. Therefore, healthcare professionals will administer the nasal spray only in settings like a doctor’s office or hospital. They will dispense the nasal spray as nasal puffs, as it is a slightly modified version of ketamine, but its effects still remain essentially the same.

Patients receiving ketamine treatment will visit their doctor once or twice a week to receive nasal puffs of the medication. Patients must stay at the doctor’s office for two hours after the treatment to avoid experiencing disorientation or confusion. Furthermore, patients should refrain from engaging in activities that require mental exertion, such as driving or operating machinery, for the rest of the day.

Esketamine nasal spray appears both effective and fast-acting for treatment-resistant depression,

Ketamine nasal spray benefits
The new drug has a potential advantage in terms of being fast-acting. According to Dr. Anand, individuals may experience a reduction in symptoms in just a few hours and it may last for several days. This is in contrast to most oral antidepressants which can take weeks to begin working.

Ketamine works differently from other depression drugs because it has major effects on glutamate, which is a different neurotransmitter that is much more prevalent in the brain. Unlike most other available antidepressants, which mainly work on the serotonin, norepinephrine, or dopamine systems, ketamine has a unique mechanism of action.

Side Effects of Ketamine Nasal Spray

The drug had some side effects, such as dizziness, dissociation, dysgeusia (change or distortion in sense of taste). These effects typically occurred shortly after taking the drug and lasted for around 90 minutes. However, the study showed that the drug was generally safe and well-tolerated.

Ketamine Nasal Downsides
Ketamine, despite being a promising antidepressant and anesthetic, comes with a few downsides. Apart from the potential side effects, it is unclear whether the drug is safe and effective for long-term use. As it impacts a significant neurochemical in the brain, interfering with it over an extended period may have unknown effects.

Furthermore, ketamine is an addictive substance, and when used improperly, it can lead to substance abuse and addiction. Dr. Anand emphasizes that the long-term effects of ketamine use remain unknown.

There is no guarantee that this treatment will work for all individuals suffering from treatment-resistant depression. Additionally, like other antidepressants, it could potentially worsen the symptoms.

• Esketamine underwent five clinical trials before being approved. Among these, only one short-term trial, along with its longer-term relapse prevention trial, showed statistically significant positive results for patients who had benefited from ketamine, according to Dr. Anand.